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The efficacy in acute migraine of oral sumatriptan was assessed in a double-blind,randomised,placebo-controlled,crossover study of 61 patients (mean age 39[SD 10]years).41 completed treatment of four attacks,two with sumatriptan 100 mg and two with placebo.The response rate(reduction in headache from moderate or severe to mild or absent at 2 h)was 51%(45/89) with sumatriptan and 10%(9/93)with placebo(p<0.01);rescue medication was needed at 2 h in 41%and 88%,respectively.Of 28 patients headache-free at 2 h,11(39%)had recurrent headache within 24 h.There were no substantial side-effects.Thus,sumatriptan is an effective well-tolerated treatment for acute migraine attacks. |
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